Sunday, December 29, 2013

What is chlortetracycline?


Aureomycin, also known as "chlortetracycline," was the first discovered tetracycline class of antibiotics. Dr Benjamin in 1945 featured from the university of Missouri SangBo plots collected soil samples isolated from Streptomyces golden (Streptomyces aureofaciens), named "aureomycin".
Antibacterial wide range, for a variety of bacteria, some patients, mycoplasma, helix and parasite inhibition; Mainly used for bacterial infections resistant to penicillin, such as pneumonia and staphylococcus aureus sepsis, typhus, mycoplasma pneumonia, amebic dysentery, etc.
Easy to cause the gastrointestinal tract after oral effects such as nausea, vomiting, diarrhea, etc.; And chlortetracycline and broad spectrum antibiotic use in a long time, because of the sensitive bacteria are destroyed, cause not sensitive bacteria or fungi blooms, which can lead to staphylococcus aureus, candida double infection, etc.
Aureomycin can combine with tRNA, so as to achieve the effect of bacteriostasis. Often used as a veterinary drug used to treat conjunctivitis.


Friday, December 27, 2013

Information about Cholesteryl benzoate (Cholesterol benzoate)



Product Name: Cholesteryl benzoate
Synonyms: 3-Benzoyloxycholest-5-ene;3-Hydroxycholest-5-ene3-benzoate;Cholest-5-en-3-ol (3beta)-, benzoate;Cholest-5-en-3-ol(3.beta.)-,benzoate;Cholest-5-en-3-yl benzoate;Cholest-5-ene-3-ol3-benzoate;CHOLESTERYL BENZOATE;CHOLESTEROL BENZOATE
CAS: 604-32-0
MF: C34H50O2
MW: 490.76
EINECS: 210-064-3
Product Categories: Cholesteryl Compounds (Liquid Crystals);Functional Materials;Liquid Crystals & Related Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;CholestericAsymmetric Synthesis;Chiral Building Blocks;Complex Molecules;Liquid Crystals;Organic Electronics and Photonics;Asymmetric Synthesis
Mol File: 604-32-0.mol



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From:pharmaceutical chemicals

Thursday, December 26, 2013

The role of Ceftazidime with purpose



Ceftazidime of the third generation of semisynthetic cephalosporins. Products for free acid (five carbohydrates), and with a certain amount of anhydrous sodium carbonate, made into injection for use. Suitable for sensitive gram-negative bacillus by sepsis, infection of lower respiratory infection, abdominal bile, complexity, urinary tract infections and severe skin soft tissue infection.
The goods to the third generation of cephalosporin class of antibiotics, antibacterial activity is stronger, has a wide antimicrobial spectrum, the gram positive or negative has strong effect. Of gram positive bacteria, negative bacteria produce beta lactamase with high stability, and the goods of pseudomonas aeruginosa, escherichia coli, white clay, bacillus proteus, enterococcus, salmonella, shigella bacteria, neisseria gonorrhea, neisseria meningitidis, s. aureus bacteria produce gas, hemolytic streptococcus, pneumococcus and bacillus has strong antimicrobial activity, such as especially for pseudomonas aeruginosa strongest antibiotics.
Can be used for the treatment of infection or by two or more mixed infection caused by sensitive bacteria. Mainly used for clinical sepsis, bacteremia, bronchitis, pneumonia, pleurisy, peritonitis, pyelonephritis, urinary tract infections, prostatitis, cystitis, ear nose and throat infections, skin and soft tissue infections, bone and joint infection, pelvic inflammation and burns, etc.

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Tuesday, December 24, 2013

What is Human serum albumin?



Human Serum Albumin, hereinafter referred to as HSA is the protein in Human plasma and its non glycosylation of single polypeptide contains 585 amino acids, the molecular weight of 66 kd. In its concentration in plasma of 42 g/L, about 60% of the plasma total protein. Human serum albumin in body fluids can transport fatty acids, bile pigment, amino acids, steroids, metal ions, and many therapeutic molecules, such as: while maintaining normal blood osmotic pressure. In clinic can be used in the treatment of burn shock and human serum albumin, used to supplement for surgery, an accident or bleeding caused by blood loss, also can be used as compatibilizer in the plasma.

Thursday, December 19, 2013

Centrophenoxine pharmaceutical analysis



Centrophenoxine main effect in the cerebral cortex, it can promote the REDOX of brain cells, regulating the metabolism of the nerve cells, increase the use of sugar to the inhibition of the central nervous excitement. Children traumatic coma, nocturia, disturbance of consciousness, senile psychosis, all kinds of dementia, alcohol, etc.
Preparation: anhydrous glacial acetic acid (calculated on water content, each 1 g 5.22 mL) of water and acetic anhydride, 750 mL, add perchlorate (70% 72%) 8.5 mL, shake well, slowly add acetic anhydride at room temperature of 23 mL, and while shaking, and after the vibration shake well again, put the cold, add right amount to make anhydrous glacial acetic acid into a 1000 mL, shake well, 24 hours a day. If the test of the acetylation, the water must be a determination method of determination of moisture content on this page, and then water and acetic anhydride to adjust to the liquid water content of 0.01% to 0.01%.
Calibration: take benchmark in 105 ℃ drying to constant weight is about 0.16 g, potassium hydrogen phthalate precision said, with no water 20 ml glacial acetic acid to dissolve, and liquid crystal violet indicator 1 drop, using the liquid slowly titration to blue, and the result of the titration correction by blank test. Each 1 ml perchloric acid titration fluid (0.1 mol/L) is equivalent to 20.42 mg of potassium hydrogen phthalate. According to the consumption of the liquid and the extraction of potassium hydrogen phthalate dosage, calculate the liquid concentration, can.
Storage: brown glass bottle, airtight preservation.

Tuesday, December 17, 2013

Information about Chlorhexidine diacetate

To associate the after-effects of an in vitro abstraction with analytic response, the furnishings of 0.005 and 0.05% chlorhexidine diacetate and 0.1 and 1.0% povidone-iodine concentrations on anguish healing were evaluated in 5 advocate dogs. Full-thickness derma wounds (2 X 2 cm) were anhydrous already circadian for 14 canicule with the antibacterial solutions or physiologic-buffered saline. Chlorhexidine diacetate 0.05% had decidedly added antibacterial action than povidone-iodine and saline, and both chlorhexidine diacetate concentrations had balance furnishings 6 hours afterwards irrigation. Neither povidone-iodine nor acrid had cogent antibacterial activity. The percentages of unhealed anguish breadth and anguish abbreviating were affected 7, 14, and 21 canicule afterwards wounding. Healed anguish breadth and abbreviating were agnate in wounds advised with chlorhexidine diacetate and povidone-iodine. However, wounds advised with chlorhexidine diacetate had added healed anguish breadth on canicule 7 and 14 and added abbreviating on canicule 7, 14, and 21 than saline-treated wounds. At the concentrations tested, chlorhexidine diacetate irrigations provided antibacterial action and were added benign to anguish healing than irrigations with acrid alone. These after-effects advance that concentrations of chlorhexidine diacetate which are cytotoxic to tissue ability fibroblasts in vitro do not baffle with anguish healing in vivo. 

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From:pharmaceutical chemicals

Thursday, December 12, 2013

Monobenzone pharmacology



4-(Benzyloxy)phenol, or Monobenzone, is an amoebic actinic in the phenol ancestors with actinic blueprint C13H12O2.[1][2] It is acclimated as a contemporary biologic for medical depigmentation.
Pharmacology:The contemporary appliance of monobenzone in animals decreases the elimination of melanin from melanocytes. The aforementioned activity is anticipation to be amenable for the depigmenting aftereffect of the biologic in humans. Monobenzone may could cause abolition of melanocytes and abiding depigmentation.
The analysis of the derma afterwards depigmentation with contemporary monobenzone is the aforementioned as that apparent in vitiligo; the covering is accustomed except for the absence of identifiable melanocytes. Therefore, monobenzone is acclimated as a contemporary anesthetic to assuredly depigment accustomed derma surrounding vitiliginous lesions alone in patients with broadcast (greater than 50 percent of physique apparent area) idiopathic vitiligo.Monobenzone is aswell getting advised for the analysis of Melanoma.


The use of Amiodarone Hydrochloride



Amiodarone hydrochloride as an angina pectoris medicine, can selectively dilate coronary blood flow, reduce myocardial oxygen consumption at the same time, slow heart rate, reduce the atrioventricular conduction velocity is similar to the effects of beta blockers.
Description: white to light yellow crystalline powder, odourless, tasteless, melting point of 153 ~ 158 ℃. Soluble in chloroform, soluble in ethanol, slightly soluble in acetone, insoluble in water.
Function and use: this medicine for angina pectoris medicine, resistance to selectively dilate coronary blood flow, reduce myocardial oxygen consumption at the same time, slow heart rate, reduce the atrioventricular conduction velocity is similar to the effects of beta blockers. Sex and ventricular tachycardia is used in room, paroxysmal atrial flutter and fibrillation, pre-excitation syndrome syndrome, also used for refractory paroxysmal tachycardia chronic coronary artery insufficiency and angina, etc.
Usage: adult oral: start 200 mg each time, 3 times a day, after a meal, after a week to maintain volume, 100 mg/time, 2-3 times a day.
Side effects: gastrointestinal symptoms: nausea, vomiting, dry mouth, abdominal distention, constipation, loss of appetite, etc. Was observed in the cardiovascular system: sinus bradycardia, sinus arrest or sinus atrial block atrioventricular block. Occasional hyperthyroidism, drug rash, itching, there is also a cornea pigmentation and pigmentation of the skin.
Taboo: room ventricular conduction block and bradycardia were banned.

Monday, December 9, 2013

The introduction of Amoxicillin



Amoxicillin, also known as Ann mo del or "Westwood, is one of the most commonly used penicillin kind of broad spectrum beta lactam antibiotics, as a kind of white powder, has a half-life of about 61.3 minutes. Stable under acid condition, gastrointestinal absorption rate of 90. Amoxicillin antiseptic effect is strong, strong ability to penetrate the cell membrane also. Is one of the widely used oral penicillin, the preparation of capsules, tablets, granules, tablets, etc. Penicillin allergy and penicillin skin test positive patients disabled.
Description: white or white crystalline powder; Taste slightly bitter. This product is slightly soluble in water, hardly soluble in ethanol. This product acid, in the gastrointestinal tract absorb good, and not easily affected by the most food. Fiber will affect the absorption, reduce the efficacy. Don't eat high-fiber foods during taking the drug, such as oats, celery, carrots, etc.

Thursday, December 5, 2013

what are the ingredients of the Inositol




Inositol is an animal, microbial growth factor. Molecular formula (CHOH) 6. Also called cyclohexanol six alcohol, widely distributed in plants and animals. The first isolated from the heart and liver. Cyclohexanol six alcohol in nature, there are several suitable isomers, but valuable, naturally occurring isomers of cis - 1, 2, 3, 5 - anti - 4, 6 - cyclohexanol six alcohol, structural formula as above. At above 80 ℃ from water or acetic acid of inositol is white crystal, melting point 253 ℃, the density of 1.752 g/cm 3 (15 ℃), sweet taste, soluble in water and acetic acid, and no optical activity. Can be made of corn soaking liquid extract. Mainly used in the treatment of cirrhosis, hepatitis, fatty liver and high blood cholesterol in disorder.
Also called cyclohexanol six alcohol. In chemistry is considered to be a multiple alkyl cyclohexane derivatives. Nine possible isomers in theory, commonly found in nature, there are four, respectively called D - chiro - inositol, L - chiro - inositol, muscle (MYO - inosi - tol) and inositol shark inositol (scyllo - inositol). One of the most common in nature is muscle inositol. D - chiro - inositol and L - chiro - inositol quantity is less, but distribution is very wide, can become the majority of methyl ether. Inositol in coconut, shark, mammals can be found in the urine. In general inositol is widespread, but on its metabolic pathways or physiological function is not very clear.


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From:Natural herbal extracts

Wednesday, December 4, 2013

The purpose of Atorvastatin Calcium




Atorvastatin Calcium to treat its total cholesterol, low density lipoprotein cholesterol and apolipoprotein B rise and elevated triglycerides. Patients with primary hypercholesterolemia, including familial hypercholesterolemia (heterozygous type) or mixed hyperlipidemia (Fredrickson taxonomy Ⅱ type a and b Ⅱ) patients, if diet therapy and other non-drug therapy efficacy are not satisfied, can be used this product. The homozygous familial hypercholesterolemia patients, atorvastatin calcium can share with other lipid-lowering therapy or used alone (when no other treatments), in order to reduce total cholesterol and low density lipoprotein cholesterol.

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From:pharmaceutical chemicals

Tuesday, December 3, 2013

What is Memantine?



Memantine is the aboriginal in a atypical chic of Alzheimer's ache medications acting on the glutamatergic arrangement by blocking NMDA receptors. It was aboriginal actinic by Eli Lilly and Company in 1968. Memantine is marketed beneath the brands Axura and Akatinol by Merz, Namenda by Forest, Ebixa and Abixa by Lundbeck and Memox by Unipharm. Memantine has been apparent to accept a bashful aftereffect in moderate-to-severe Alzheimer's ache and in dementia with Lewy bodies.Despite years of research, there is little affirmation of aftereffect in balmy Alzheimer's disease.


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From:Natural herbal extracts

Thursday, November 21, 2013

Information about ApoB48 ELISA Kit



Apolipoprotein B (ApoB) are the primary apolipoproteins of chylomicrons and low-density lipoproteins (LDL - accepted frequently by the misnomer "bad cholesterol" if in advertence to affection disease), which is amenable for accustomed cholesterol to tissues. While it is cryptic actually what anatomic role ApoB plays in LDL, it is the primary apolipoprotein basic and is actually appropriate for its formation. What is bright is that the ApoB on the LDL atom acts as a ligand for LDL receptors in assorted beef throughout the physique (i.e. beneath formally, ApoB "unlocks" the doors to beef and thereby delivers cholesterol to them). Through a apparatus that is not absolutely understood, top levels of ApoB can advance to plaques that could cause vascular ache (atherosclerosis), arch to affection disease. There is ample affirmation that levels of ApoB are a bigger indicator of affection ache accident than absolute cholesterol or LDL. However, primarily for celebrated reasons, cholesterol, and added specifically, LDL-cholesterol, charcoal the primary lipid analysis for the accident agency of atherosclerosis.

Wednesday, November 20, 2013

What is frovatriptan?



Frovatriptan is a triptan biologic developed by Vernalis for the analysis of cephalalgia headaches and for abbreviate appellation blockage of menstrual migraine. The artefact is accountant to Endo Pharmaceuticals in North America and Menarini in Europe.
Adverse effects:Serious but attenuate cardiac contest accept been appear in patients with accident factors predictive of CAD. These include: coronary avenue vasospasm, brief myocardial ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation.


Sunday, November 17, 2013

The purpose of the Ammonium hydrogen difluoride





Ammonium hydrogen difluoride is a kind of corrosive chemicals, in the tide, water decomposition of toxic fluoride, nitrogen oxide and ammonia gas. For acid soluble in water, can dissolve glass, slightly soluble in alcohol, easily soluble in cold water, and very easy deliquescence.
USES: used as glass etching agent, disinfectant, preservatives, metal beryllium solvents, silicon steel sheet surface treating agent, also used in the manufacture of ceramic and magnesium alloys.
Can be used as chemical reagent, glass etching agent (often with hydrofluoric acid and), fermentation industrial disinfectant and preservative, from beryllium oxide metal beryllium solvent system, and the silicon steel sheet surface treating agent. Also used in the manufacture of ceramics, magnesium alloy, the boiler feed water system and steam generating system of cleaning cleaning, and oilfield sandstone acidizing. Also used as alkylation, isomerization catalyst component.


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From:Metal Cleaning Agent

Thursday, November 7, 2013

What is N6-Methyladenosine?





N6-Methyladenosine (m6A ) is an abounding modification in mRNA and is begin aural some viruses, and a lot of eukaryotes including mammals, insects, plants and yeast. It is aswell begin in tRNA, rRNA, and baby nuclear RNA (snRNA) as able-bodied as several continued non-coding RNA, such as Xist.
Adenosine methylation is directed by a ample m6A methyltransferase circuitous absolute METTL3 as the SAM-binding sub-unit. In vitro, this methyltransferase circuitous preferentially methylates RNA oligonucleotides absolute GGACU and a agnate alternative was articular in vivo in mapped m6A sites in Rous bump virus genomic RNA and in bovine prolactin mRNA.


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From:Chemical Reagent

Tuesday, November 5, 2013




Bodybuilding:Despite the abridgement of any accepted ameliorative applications, the biologic remained acknowledged until the aboriginal 2001. The United States Congress added assertive kinds of steroids which may or may not cover methandrostenolone to the Controlled Substances Act as an alteration accepted as the Anabolic Steroid Control Act of 1990. This act placed steroids in the aforementioned class as some amphetamines as a "Schedule III" biologic and control of these drugs after-effects in a felony. Contrary to accepted belief, steroids were banned by Congress after the abutment of the FDA, the American Medical Association, the DEA or the National Institute on Biologic Abuse. It's acclimated by bodybuilders, and methandrostenolone continues to be acclimated illegally to this day, about getting accumulated (stacked) with injectable compounds, such as testosterone propionate, enanthate, cypionate as able-bodied as added injectable drugs like trenbolone acetate.

Sunday, November 3, 2013

The properties of the Platinum wire





Platinum is a kind of transition metals, density is big, can be extended, colour and lustre is silvery white, metallic luster, hardness is 4-4.5, the relative density of 21.45. High melting point is 1773 ℃. Rich ductility, can pull very thin platinum wire, rolling into a thin platinum foil. Chemical properties of stability, not soluble in strong acid, alkali, not oxidized in the air. But the following material can dissolve platinum:
Aqua regia (nitric acid and hydrochloric acid in the mixture of 1:3 (volume)
Although wang can dissolve platinum, but it is associated with the status of platinum, the density of platinum aqua regia dissolving speed is very slow at room temperature, platinum wire 1 mm in diameter to 4-5 hours can be completely dissolved. Platinum black powder (platinum) that can react with sulfuric acid when heated to generate Pt (SO4) 2, SO2 and water. Method of producing chloroplatinic acid is the platinum dissolved in aqua regia. The product of this reaction is H2PtCl6, rather than previously thought, nitrogen platinum compounds. Chloroplatinic acid is a reddish brown solid, the solution obtained from evaporation.




Wednesday, October 30, 2013

What is Cadmium sulfate?





Cadmium sulfate colorless monoclinic crystal. No smell. Heated to over 40 degrees to dehydrate, to over 80 degrees in a hydrate, but continue to heat not become grey anhydride. Soluble in water, almost insoluble in alcohol and ethyl acetate and ethyl ether
Purpose: electrolytic deposition of cadmium, copper, nickel, cadmium, manufacturing standard horse for the hui arsenic method of catalyst, determination of hydrogen sulfide, fumaric acid, cadmium plating. Pharmaceutical industry used as the eyewash such as keratitis antiseptic and astringent, as protective agent for polyethylene plastic industry, battery industry for cadmium cell, weston batteries and other standard cell electrolyte, fertilizer production, chemical fertilizer industry for cadmium cadmium salt is also used to other manufacturing.


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From:Metal oxide materials

Sodium camphorsulfonate related information





Pharmacological effects:
(1) Sodium camphorsulfonate is central nervous excitement medicine. Has the effect that the excitement of camphor respiration and circulation, but not lasting. Camphor after absorption in the body after oxidation oxidation camphor, can excited the cerebral cortex, medulla respiratory center and vascular sports center, can also directly exciting heart. Suitable for acute respiratory and circulation obstacle, against the poisoning of CNS depressants, etc. And can play a strong heart, improve blood circulation, promote metabolism function.
(2) can also be used as a spin light body separation of split agent.
5, scope of application:
(1) of this article used the central inhibition of poisoning and pneumonia, intestinal disease caused by respiratory depression and decline in circulation function and respiratory function. Mainly used in respiratory depression, difficulty breathing, indigestion, stomach function drops, heart failure, blood pressure to drop, the symptom such as insufficient blood supply.
(2) in recent years, the study found that the product and enhance the body's immune function, promote the feed intake, improve individual's state of mind, promote the sick obligated to accelerate the recovery of function.
(3) in addition to the water dosage forms, veterinary powder powder have been extensively applied to the powder, mix powder business agent of drinking water, as a auxiliary drug, can play a good curative effect, is helpful to promote the rapid recovery of the body. Provided by peng trade co., LTD., jinan mountain friendship.


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From:pharmaceutical chemicals

Wednesday, October 23, 2013

The purpose of Copper (II) oxide powder





Copper(II) oxide or cupric oxide (CuO) is the college oxide of copper. As a mineral, it is accepted as tenorite.
Uses:
Cupric oxide is acclimated as a colorant in ceramics to aftermath blue, red, and blooming (and sometimes gray, pink, or black) glazes. It is aswell acclimated to aftermath cuprammonium hydroxide solutions, acclimated to accomplish rayon. It is aswell occasionally acclimated as a comestible supplement in animals, adjoin chestnut deficiency. Copper(II) oxide has appliance as a p-type semiconductor, because it has a attenuated bandage gap of 1.2 eV. It is an annoying acclimated to brightness optical equipment. Cupric oxide can be acclimated to aftermath dry corpuscle batteries. It has aswell been acclimated in wet corpuscle batteries as the cathode, with lithium as an anode, and dioxalane alloyed with lithium perchlorate as the electrolyte. Copper(II) oxide can be acclimated to aftermath added chestnut salts. It is aswell acclimated if adjustment with chestnut alloys.
Another use for cupric oxide is as a acting for adamant oxide in thermite. This can about-face the thermite from an damaging to a low explosive.


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From:Organic Chemical Compound

The basic information of the Ethyl-4-bromobutyrate





Chinese name: 4 - bromine ethyl butyrate
English synonyms: Ethyl-4-bromobutyrate; 4 - bromine ethyl butyrate; 4 - bromine ethyl butyrate, 98%
English name: 4 - bromobutyrate baton rouge
English synonyms: 4 - Bromobutanoic acid, baton rouge ester; BrCH2CH2CH2C OC2H5 (O); Butanoic acid, 4 - bromo -, baton rouge ester; 4 - bromobutanoate baton rouge; Baton rouge gamma - bromobutyrate; Baton rouge 4 - BROMO - N - BUTYRATE; 4 - BROMOBUTYRATE baton rouge; Baton rouge GAMMA - BROMO - N - BUTYRATE
CAS no. : 2969-81-5
Molecular formula: C6H11BrO2
Molecular weight: 195.05
EINECS no. : 221-005-6
Related categories: Acids and Esters; Bromine come; Of C6 to C7. Carbonyl come; Esters. Carbonyl compounds; intermediates
Mol files: 2969-81-5. Mol


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From:pharmaceutical chemicals

Monday, October 21, 2013

Some of the efficacy of Teicoplanin



Teicoplanin is an antibacterial acclimated in the prophylaxis and analysis of austere infections acquired by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and Enterococcus faecalis. It is a semisynthetic glycopeptide antibacterial with a spectrum of activity agnate to vancomycin. Its apparatus of activity is to arrest bacterial corpuscle bank synthesis..
Oral teicoplanin has been approved to be able in the analysis of pseudomembranous colitis and Clostridium difficile-associated diarrhoea, with commensurable ability with vancomycin.
Its backbone is advised to be due to the breadth of the hydrocarbon chain


Tuesday, October 15, 2013

5-Bromo-3 (2H)-benzofuranone basic information





CAS: 54450-20-3
Chemical Name: 3 (2H)-BENZOFURANONE, 6-BROMO-
English Synonyms: 6-Bromo-benzofuran; 6-Iodo-3-Benzofuranone; 5-Iodo-3-Benzofuranone; 6-BROMO-BENZOFURAN-3-ONE; 5-Bromo-3 (2H)-benzofuranone; 5-Bromobenzo [b] furan-3 (2H)-one; 6-broMo-2 ,3-dihydro-1-benzofuran-3-one; 5-Bromocoumaran-3-one, 5-Bromo-1-benzofuran-3 (2H) - one
Chinese Name: 5 - bromo-3 - benzofuranone
Chinese Synonyms: 6 - bromo-3 - phthalide; 5 - bromo-3 - phthalide; 5-Bromo-3(2H)-benzofuranone
CBNumber: CB3280311
Formula: C8H5BrO2
Molecular Weight: 213.03
MOL File: 54450-20-3.mol


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From:pharmaceutical chemicals

Sunday, October 13, 2013

What is Starch?





Starch is a high polymer of glucose , Qianfen known in the catering industry , the general formula (C6H10O5) n, hydrolysis of the disaccharide maltose stage , the chemical formula (C12H22O11), obtained after complete hydrolysis of glucose , chemical formula (C6H12O6). There starch amylose and amylopectin categories. Starch is the storage of nutrients in plants , seeds and tubers stored in , the types of plants have a high content of starch .
Starch (amylum) is a polysaccharide . Starch manufacture is a form of energy storage plants . Formula (C6H10O5) n.
Amylose starch can be divided into ( amylose ) and amylopectin ( starch glue ) . The former is no branch of the helical structure ; the latter 24 to 30 glucose residues in α-1, 4 - glycosidic bond connected to each other , at the office of branched-chain α-1, 6 - glycosidic bond .
Amylose case of iodine was blue, iodine amylopectin was purple . This is not a starch undergoes a chemical reaction with iodine (reaction), but from the interaction (interaction), but starch screw hole just big enough for the central iodine molecules through van der Waals forces , the two form a blue- black malocclusion thereof. Experimental results show that the iodine molecules can not separate the starch blue , in fact, a blue starch iodine ions (I3).


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From:Metal Cleaning Agent

Friday, October 11, 2013

The main purpose of Sodium Metabisulphite1





Sodium metabisulfite (Sodium Metabisulphite1) as a white or yellow crystalline powder or small crystals , with a strong smell of SO2 , the proportion of 1.4 , soluble in water , acidic aqueous solution , with a strong acid contact with the release SO2 and generate the corresponding salts, long home air , then oxidized into Na2S2O6, so the product can go far. Higher than 150 degrees Celsius, ie the decomposition of SO2.

The main purpose
Chemical industry: used in the production of sodium hydrosulfite , sulfamethazine dipyrone , caprolactam , etc., and chloroform , styrene sulfone and benzaldehyde purification. Photographic industry as a fixer ingredients. Perfume industry for the production of vanillin . Used as a preservative brewing industry , rubber coagulant and bleached cotton dechlorination agent. Organic intermediates , dyes , tanning as a reducing agent for electroplating industry, oilfield wastewater treatment as well as for mine processing agents .
Industry: industry for dyeing, organic synthesis , printing , leather , pharmaceutical and other sectors ; as a preservative in food processing , bleaching agents, bulking agent .
As chemical reagents: ( printing and photography , etc. ) , used as a bleaching agent mordant, reducing rubber coagulant , also used in organic synthesis, pharmaceutical and spices.


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From:metal materials

IM-54 role





A cell-permeable mono-indolylmaleimide admixture that selectively blocks oxidative stress-induced baleful corpuscle afterlife (~3 µM IM-54 prevented ~50% corpuscle afterlife in HL60 beef apparent to 100 µM H2O2). Does not action aegis adjoin Etoposide- (Cat. No. 341205) induced apoptosis or affectation antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as top as 50 µM.
CAS No.:861891-50-1
Yellow orange solid. Packaged beneath apathetic gas.
Storage Conditions:Shipped at Ambient Temperature. Store at +2 - 8°C.
Properties:
Solubility: DMSO (100 mg/ml) or Methanol (10 mg/ml).PubChem ID:26759222
Empirical Formula:C19H23N3O2
Alternate Names:2-(1H-Indol-3-yl)-3-pentylamino-maleimide
Oxidative stress-induced afterlife plays an important role in ischemia-reperfusion injury, such as achievement and affection attack. Here, we call the development of careful inhibitors of necrosis, MS-1 and IM-54, as abeyant cardioprotective agents and biological accoutrement for investigating the atomic mechanisms of corpuscle death. By agency of actinic modifications of kinase inhibitor BM I, its affection for assorted kinases was auspiciously removed and a almighty and careful inhibitor of necrosis, IM-54, was obtained. IM-54 inhibits afterlife induced by oxidative stress, but not apoptosis induced by anticancer drugs.


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From:Raw pharmaceutical materials

Wednesday, October 9, 2013

Heptanol 's HANDLING AND STORAGE




Heptanol natural products present in lilac , hyacinth, violet leaves and other essential oils . Slightly soluble in water , ethanol , ether and other segments. Oxidizable and esterification . Present in fusel oil. Reducing the n-heptyl aldehyde , n-pentyl bromide or magnesium oxide synthesis. Reagents for Organic Synthesis .
HANDLING AND STORAGE :
Handling Precautions : closed operation, full ventilation. The operator must go through specialized training, strict adherence to rules. Proposed operators wear self-absorption filter respirators ( half-mask ) , wearing chemical protective safety glasses, wear protective overalls on infiltration , wear rubber gloves. Keep away from fire , heat, workplace smoking . Use explosion-proof ventilation systems and equipment . Prevent vapor leakage into the workplace air. Avoid contact with oxidants . Handling of light when light unloading, packaging and containers to prevent damage . Equipped with the appropriate variety and quantity of fire equipment and emergency equipment leakage . Empty containers may be harmful residues .
Storage Precautions : Store in a cool, ventilated warehouse. Keep away from fire and heat. Should oxidants , food chemicals stored separately and avoid mixing reservoir. Equipped with the appropriate variety and quantity of fire equipment . Storage areas should be equipped with spill response equipment and materials suitable host .


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From:Base chemicals

Tuesday, October 8, 2013

Natural carotene role




1, to maintain the integrity of skin and mucous membrane
Carotene [1] into vitamin A, the stimulation of mucosal cells continue to secrete mucus, mucus covering the surface of the cell, to prevent bacterial attack, usually 6-7 days mucosal cells is updated, if the lack of vitamin A, the body will not be able timely repair mucosa.
2, protect eyesight
Carotene to promote the generation of light-sensitive pigment, strengthen eyesight form; contribute to the synthesis of rhodopsin, improve dark adaptation, prevent night blindness.
3, anti-cancer changes
Carotene can reduce cancer patients undergoing radiation and chemotherapy toxicity arising, maintaining microsomal membrane integrity, preventing normal cell cancerous.
4, immunomodulatory
Carotene can enhance immune cell number and viability, contribute to the eradication of exogenous pathogens and the infected cells.
5, anti-aging
Carotene can not only directly scavenge free radicals, but also increase the body of superoxide dismutase and glutathione peroxidase levels, thereby delaying aging.



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From:Herbal extract

Thursday, August 29, 2013

About clove oil products


Clove oil is a tropical Southeast Asian origin of medicinal plants spices fragrant myrtle cordingly child is an alias chicken tongue clove aroma, clove, Ding of incense; public clove, mother cloves), scientific name (Eugenia caryophyllata.) refining and came as a pale yellow or colorless clear oily liquid, with special aroma of cloves gas. Exposed in air or stored course of time, then gradually thick and pale brown (see right). Insoluble in water, soluble in alcohol, ether, or glacial acetic acid. Specific gravity of 1.038-1.060.

Cloves, evergreen tree, up to 10 meters. Leaves opposite; petiole obvious; leaf blade oblong-ovate or oblong obovate, 5-10cm, width 2.5-5cm, apex acuminate or acute, base narrow down often develop into a pattern, entire. Fragrant flowers, into the top students thyrses, flower diameter of about 6mm; calyx hypertrophy, green, turn purple, tubular, apex 4 lobed, lobes triangular; corolla white, slightly purple, short tube volt, 4-lobed; stamens most, anthers diastema; ovary, and calyx tube Hopson, style thick, stigma is not obvious. Berries red-brown, rectangular oval, 1-1.5cm, diameter 5-8mm, apex persistent sepals. Seed rectangle.
With side:
1 hiccup cure stomach and vomiting worse: clove oil, rub thoroughly in the hospital. 2 rule chills stomach: clove wine kimono. 3 Warm pubic region, in addition to watery diarrhea: clove oil painted warm umbilical Plaster. 4. Bulk swelling ruffian: clove oil painted navel. 5. Governance arthralgia: clove oil rubbed raw. 3. Cure bad breath: clove oil wipe teeth. 5 Solution crab poisoning: a drop of clove oil, served with ginger. (1 party following a "Checklist Supplements") 8. Governance infestation toothache (non-inflammatory pain): a little clove oil, cotton balls dipped in a small, embedded within a wormhole.


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From:Natural herbal extracts

Wednesday, August 28, 2013

Melanotan II Acetate basic information





CAS Number: 121062-08-6
English name: Melanotan II
English Synonyms: MT2; MTII; MT-Ⅱ; Melanotan Ц; Melanotan 2; MalanotanIi; MELANOTAN II; Mt-Ii (Melanotan); MelanotanAcetate; Melanotan Ⅱ Acetate
Chinese name: Melanotan II
Chinese Synonyms: America melanin; Melanotan 2; America that Nuotan II; Melanotan II; acetate Melanotan 2; acetate Melanotan II; acetate Melanotan acetate; acetate Merano Tan Ⅱ MELANOTAN Ⅱ ACETATE; acetate Melanotan Ⅱ MELANOTANII ACETATE (MT-2)
CBNumber: CB9213757
Formula: C50H69N15O9
MW: 1024.18
MOL File: 121062-08-6.mol
Melanotan II chemical properties
Density: 1.43
Storage conditions: -20 ° C
Solubility: H2O: 5 mg / mL, soluble
form: solid
CAS databases: 121062-08-6 (CAS DataBase Reference)


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Tuesday, August 27, 2013

Magical Argireline Acetate (Acetyl Hexapeptide-3)




Argireline Acetate (Acetyl Hexapeptide-3) from the Antarctic Bay Bing Heni found in the concentration of bacteria called unicellular green bacteria are developed six yuan peptides, and completely MP clean room production process that produced potent polypeptide protein; this bioactive peptides hexagonal, effective relief and inhibit forehead wrinkles, fine lines and the surrounding fish eye muscle contraction and activities to help relax the muscles, so that the skin supple and elastic tissue to restore smooth line.
It has a similar inhibits neurotransmitter, blocking neuromuscular conduction function, to avoid excessive muscle contraction, can prevent the formation of fine lines. Six yuan peptides can reduce the strength of muscle contraction can be slow, let the muscles relax, reduce the dynamic pattern of occurrence and elimination of wrinkles; effectively reorganize collagen elastin, can increase the activity of elastin, so relax facial lines, wrinkles and smoothes improve relaxation. Can be used in cosmetics as an anti-wrinkle ingredients, and excellent results.
Argireline is a class of botulinum toxin components, with all the features of botulinum toxin, which does not contain any toxic, non-toxic substances. The main ingredient is composed of six amino acids arranged in a combination of biochemical products. While Botox is often compared and their mechanisms are completely different. Six peptides can intercept signals of muscle contraction to reduce the force of muscle contraction, thereby improving the depth and length of fine lines. It has become a place of striking beauty Botox darling. Swiss Legend Group skincare R & D Labs in 2010 Magic MAGIC CARE Care six peptides (like Botox) wrinkle firming peptide stock solution is six representatives tip of beauty products.


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Sunday, August 25, 2013

Salcitonin Acetate Introduction


Calcitonin is the regulation of calcium metabolism, parathyroid hormone inhibition of one, it can significantly reduce the high turnover bone disease of bone loss, such as osteoporosis, deformed bone disease (Paget's disease), pain nerve dystrophy (Sudeck's disease) and malignant osteolysis syndrome, its postmenopausal osteoporosis bone torso more significant effects than limbs and high turnover bone disease than the low turnover bone disease more pronounced. Can inhibit osteoclast activity, and stimulation of osteoblast formation. Calcitonin also inhibits osteolysis, so pathologically elevated blood calcium concentration is reduced, and by reducing the increase tubular reabsorption calcium, phosphorus and sodium excretion, serum calcium but does not fall below the normal range . Calcitonin inhibition of gastric and pancreatic secretory activity, but does not affect the stomach and intestines. Clinical trials prove that the product of some painful bone disease in patients with analgesic effect. All calcitonin structurally similar, with a single chain of 32 amino acids arranged differently. Sequence of amino acids depending on the species. Salmon calcitonin its receptor with high affinity binding site (receptor binding site of its central nervous system has been shown in certain regions), with a very good clinical results and ratio combining mammals (including humans) calcitonin, effect lasted longer.
Salcitonin Acetate indications:
1, disabled, or can not use conventional estrogen combination therapy with calcium preparations early and late postmenopausal osteoporosis and senile osteoporosis.
2, secondary to breast, lung or kidney cancer, myeloma and other malignant hypercalcemia caused by bone metastases.
3, Paget's disease.
4, hyperparathyroidism, lack of activity or vitamin D intoxication (including acute or chronic toxicity).
5, painful nerve dystrophy or Sudeck's disease.

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Thursday, August 22, 2013

What is Oxytocin Acetate and the effects on the fetus





Oxytocin also known as Oxytocin Acetate is a pituitary neurohormone, is commonly referred to as "birth needle" [1], the supraoptic nucleus and paraventricular nucleus of the giant cell manufactured by the hypothalamic-pituitary axis transported to the nerve fibers to the posterior pituitary secretion, and then released into the blood. Mainly used in clinical birth abortion, postpartum bleeding and shortened third stage of labor. Besides a wide range of physiological functions, especially the role of the central nervous system.
Oxytocin is a hormone produced in the brain, both men and women. In women, it can cause uterine contractions during childbirth and stimulate milk secretion, and through maternal affection between mother and child to establish contact. In addition, it also reduces the human body such as stress hormone corticosterone levels, lower blood pressure.
Oxytocin stimulate the secretion of breast and uterine contraction dual role to stimulate breast-based, its physiological role and regulation of secretion described below.
Oxytocin is a close relationship between people's origins, the reason why people are eager to embrace love kissing precisely because oxytocin at work. Oxytocin levels rise when the body, it will subsequently be able to release a lot of stress relief, anti-aging hormone, better promote cell regeneration.
Effects on the fetus: oxytocin can be selectively excited uterine smooth muscle, causing contraction of the uterus, is a strong uterine contractions agent, mainly used for oxytocin, induction of labor and the prevention of postpartum hemorrhage. Intravenous infusion of oxytocin effect occurs 1 minute, so the speed can be adjusted to control the dose infusion, thereby controlling the intensity of uterine contractions. In childbirth if they can properly use, you can play a good induction or strengthen the role of uterine contractions, also known as birth role in the clinical application is extremely broad. But the application of oxytocin, it must be strictly medication methods, including the route of administration, medication velocity and concentration, with or without medication contraindications psychosis.
Oxytocin drug itself is not much impact on the fetus, but if oxytocin infusion rate is too fast, too much administration, may cause tonic or spasmodic contraction of the uterus, due to continued strong contraction of the uterus but not diastolic or diastolic very short time because of the birth canal stenosis or fetus is too large, malposition, etc., hinder the fetus, and the result caused by the lower uterine segment thinner and eventually rupture, causing bleeding pregnant women, fetal hypoxia. Or as a result of the above cause strong uterine contractions, childbirth without too much resistance when the fetus was delivered quickly, the entire production process is not more than three hours, called radical production. This will disinfect because of too late to protect the perineum, resulting in postpartum infection, birth canal laceration, neonatal fall injuries and other consequences. And if the contractions of long duration, intermittent short or without intermittent, affecting placental blood circulation, can easily cause acute fetal hypoxia, causing stillbirth or neonatal asphyxia


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Tuesday, August 20, 2013

Bivalirudin Trifluoroacetate role




Bivalirudin Trifluoroacetate role with heparin, it does not rely on antithrombin 1V (NI1_ Ⅳ), heparin cofactor Ⅱ and so on. Thrombin plays a central role in the coagulation serine protease: it is the hydrolysis of fibrinogen to generate fibrin monomers; activation of coagulation factor X Ⅲ; promote crosslinking of fibrin clots to form a stable covalent structure. Meanwhile, thrombin activates factor V, Ⅷ; activates platelets promote platelet aggregation and granule release. This product can be hydrolyzed due to thrombin peptide sequence Arg3 and Pro4 peptide bond between, so that the product inactivation, so the product of thrombin inhibition is reversible and transient. In in vitro experiments, the product concentration-dependent manner to extend the healthy human plasma activated partial thromboplastin time (activated partial thromboplastin time, af T), thrombin time (thrombin time, 1vr), prothrombin time (prothrombin time, PT ). The goods and the free thrombin or thrombus thrombin binding without affecting platelet release substances. Trial in healthy volunteers show: This product dose and concentration-dependent manner activated clotting time extension (activated clotting time, ACT), af Ding, Prr and 1vr. Due to vascular occlusion ≥ 70% while receiving percutaneous transluminal coronary angioplasty (PTCA) in patients with coronary heart disease treatment given after the product is also available with the same anticoagulant effect of healthy people. In the generation after intravenous anticoagulant effect of this product, the patient's coagulation in about 1 h after discontinuation tended to be normal. 291 cases due to vascular occlusion greater than 70% while receiving PTCA in patients treated with the dose increased, the majority of patients with ACI, time to reach the 300 or 350S. iv 1 mg'kg this product, combined 2.5 mg · kg · h infusion for 4h, and then 0.2 mg · kg · h dose to maintain 14 to 20h, all patients A (vr values ​​exceed 300S.

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Tuesday, August 13, 2013

Some information about Histrelin Acetate




Histrelin Acetate is an effective, long-lasting and synthetic non-peptide gonadotropin-releasing hormone analogues. It is more than endogenous gonadotropin-releasing hormone more effective. Long-term use of gonadotropin-releasing hormone agonists can reduce the number of pituitary gonadotropin receptors, also inhibits gonadotropin receptor stimulation. In the ovary, gonadotropin-releasing hormone agonist suppression steroid substances produced and reducing the number of gonadotropin receptors. Histrelin Acetate for central precocious puberty. Give proper daily dose of histrelin with central precocious puberty in boys make gonadotropin levels fall and testicular nucleic acids decrease. The girl in serum estradiol concentrations decreased to prepubertal levels, cessation of menstruation, linear growth, skeletal maturation and adult slow increase in height.

There are some indications that melatonin is involved in puberty. Nevertheless, with the Histrelin Acetate central precocious puberty in girls with estrogen reduced, but did not decrease the concentration of melatonin.

Indications:
For the treatment of central precocious puberty. Can also be used to treat endometriosis, polycystic ovarian disease, uterine leiomyoma. Also with estrogen or progesterone combined therapy of severe pre-menopausal syndrome. FDA alone can prevent acute intermittent porphyria.

Adverse reactions:
Clinical Trials common adverse reactions were injection site skin reactions (erythema, swelling and itching), vaginal bleeding, urticaria, purpura, convulsions frequency increases, visual clutter, hot flushes / flushing, swelling, mood changes, and behavioral disorder and fever , limb pain, fatigue, chills, malaise, neck, chest or trunk pain and viral infections, weight gain, head / facial pain, nausea and vomiting.

Contraindications:
Pregnant or potentially pregnant women and lactating women disabled histrelin. Hypersensitivity reaction to the drug people are disabled.



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Monday, August 12, 2013

GRF (human) Acetate basic information





Chinese name: Growing releasing hormone
Chinese Synonyms: Growing releasing hormone; promote release of adrenaline factor; acetic acid pro adrenaline-releasing factor (human); promoting adrenaline-releasing factor (human); TYR-ALA-ASP-ALA-ILE-PHE-THR-ASN-SER-TYR-ARG-LYS-VAL-LEU-GLY-GLN-LEU-SER-ALA-ARG-LYS-LEU-LEU-GLN-ASP-ILE-MET-SER-ARG-GLN-GLN-GLY-GLU-SER-ASN-GLN-GLU-ARG-GLY-ALA-ARG-ALA-ARG-LEU-NH2; GRF (human) Acetate
Name: GRF (1-44) (HUMAN)
English Synonyms: SERMORELIN (HUMAN); SOMATOCRININ (HUMAN); SOMATOLIBERIN (HUMAN); SOMATORELIN; YADAIFTNSYRKVLGQLSARKLLQDIMSRQQGESNQERGARARL-NH2; TYR-ALA-ASP-ALA-ILE-PHE-THR-ASN-SER-TYR-ARG-LYS-VAL-LEU-GLY-GLN-LEU-SER-ALA-ARG-LYS-LEU-LEU-GLN-ASP-ILE-MET-SER-ARG-GLN-GLN-GLY-GLU-SER-ASN-GLN-GLU-ARG-GLY-ALA-ARG-ALA-ARG-LEU-NH2; H-TYR-ALA-ASP-ALA-ILE-PHE-THR-ASN-SER-TYR-ARG-LYS-VAL-LEU-GLY-GLN-LEU-SER-ALA-ARG-LYS-LEU-LEU-GLN-ASP-ILE-MET-SER-ARG-GLN-GLN-GLY-GLU-SER-ASN-GLN-GLU-ARG-GLY-ALA-ARG-ALA-ARG-LEU-NH2; H-TYR-ALA-ASP-ALA-ILE-PHE-THR-ASN-SER-TYR-ARG-LYS-VAL-LEU-GLY-GLN-LEU-SER-ALA-ARG-LYS-LEU-LEU-GLN-ASP-ILE-MET-SER-ARG-GLN-GLN-GLY-GLU-SER-ASN-GLN-GLU-ARG-GLY-ALA-ARG-ALA-ARG-LEU-OH
CAS: 83930-13-6
Formula: C215H358N72O66S1
MW: 5039.65
EINECS Number:
Related Categories: Peptide; peptide APIs; Peptide; VIP and PACAP receptor
Mol File: Mol File
The nature of the growth hormone release
Storage conditions -20 ° C



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Tuesday, August 6, 2013

Some of the role of Endothelin 1



Endothelin (endothelin, ET) exists not only in vascular endothelium, is also widely present in various tissues and cells, is an important factor in regulating cardiovascular function, based on the maintenance of vascular tone and homeostasis plays an important role in the cardiovascular system. It is a polypeptide composed of 21 amino acids, a molecular weight of 2400D, N terminal position of the two cysteine ​​disulfide to connect 1-15,3-11, C is the number of hydrophobic amino terminal residues. N-terminal structure determines its receptor affinity, C-terminal receptor binding to determine their position. ET-1 and two isomers of the family that ET-2, ET-3, the difference is the individual amino acid residues play a major role in the cardiovascular is ET-1 (Endothelin 1). Endothelial cells are stimulated synthesis and release of ET-1, which is mainly regulated at the transcriptional level, stimulating ET-1 synthesis include: epinephrine, thromboxane, vasopressin, angiotensin, insulin, cytokines, and vascular wall shear force and the pressure change and the physico-chemical factors such as hypoxia, ET-1 stimulation of the synthesis process requires a Ca2 (-dependent protein kinase C (PKC) involved. inhibition of ET-1 synthesis factors: NO, PGI2, Atrial natriuretic peptide and heparin. ET-1 in plasma half-life is very short (<5min), quickly binds to receptors on the organization, its clear position mainly in the lungs and kidney, ET-degrading enzymes will soon be decomposed .

Role: endothelin (Endothelin, ET) is a Japanese scholar Yanagisawa, etc. from cultured porcine aortic endothelial cells, a kind of isolated and purified by a 21 amino acid residues of the peptide, endothelin is by far the most powerful vasoconstrictor known substances, their duration of action lasting, not for  receptors, H1 receptors and 5-HT receptor antagonist antagonist, may be isoproterenol, atrial natriuretic peptide and calcitonin gene-related peptide hormone suppression. Thus, endothelin is an endogenous vasoconstrictor long-acting regulatory factors. Endothelin there is a strong positive inotropic effect and vasoconstrictor reflex rise of blood pressure effects can also cause heart suppression, resulting in cardiac insufficiency. But also induced myocardial cell sugar overload, arrhythmias, and myocardial energy metabolism. Currently a large number of studies have shown hinder severe angina, AMI, myocardial 1 / R injury, percutaneous transluminal angioplasty ET synthesis and release of the body to increase significantly hinder, or vascular reactivity for ET hyperthyroidism, are likely to promote the development of the pathological process. The application of ET or ET antagonist antibody may be ischemic heart disease prevention.

Impact: The discovery of endothelin people on endothelial cells to further deepen the understanding that the endothelium is not only a semi-permeable membrane to maintain blood flow and exchange of material, is also a specialized regulatory organization, plays a signal receiving, processing and re-export of role for the maintenance of homeostasis plays an important regulatory role in circulation. Studies have shown that tissue hypoxia, oxidative metabolism can be enhanced and increased levels of catecholamine stimulation of endothelin original transcription. Angiotensin can promote the release of endothelin. In the heart and blood vessels have extensive endothelin receptors, endothelin receptor binding and tissue corresponding to activate the second information cGMP, secondary to increased levels of inositol triphosphate-induced increase in intracellular calcium, and exerts its biological effects .



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From:Cytokines products

Monday, August 5, 2013

Testosterone decanoate some of the information



Abstract:We have investigated the pharmacokinetics and effects on the male reproductive axis of a novel preparation of testosterone decanoate (TD) with a progestogen implant. Twenty healthy Chinese men were administered TD (400 mg intramuscular 4 weekly) with two subcutaneous (SC) etonogestrel implants. Trough testosterone concentrations rose with repeated administration. Peak concentrations 1 week after the fourth injection were 31 +/- 2 nmol/liter. Both LH and FSH were rapidly suppressed and continued to fall during treatment. Spermatogenesis was also suppressed, to <or=1 x 10(6)/mL in all men with 16 (80%) azoospermic at 12 weeks. Treatment was associated with an increase in weight, and also increases in hemoglobin concentration (9%) and hematocrit (15%). No subjects withdrew from the study, although the study was terminated after subjects had completed 12 to 18 weeks as some men were found to have elevated liver enzyme tests. These data demonstrate that the pharmacokinetics of TD are improved compared to previous injectable testosterone preparations, although peak testosterone concentrations rise briefly into the supraphysiological range. The speed and degree of spermatogenic suppression suggest that this combination has promise as an effective male contraceptive.

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Thursday, August 1, 2013

About Methandrodtenolone Products




Methandrostenolone (trade names Averbol, Dianabol, Danabol), aswell accepted as metandienone (INN) or methandienone, is an orally-effective anabolic steroid originally developed in Germany and arise in the US in the aboriginal 1960s by Ciba Specialty Chemicals. Methandrostenolone is a controlled actuality in the United States and Western Europe and charcoal accepted a part of bodybuilders. An injectable anatomy is awash online from United States based companies. Methandrostenolone is readily accessible after a decree in countries such as Mexico (under the barter name Reforvit-b), and is aswell getting bogus in Asia and abounding East European countries.

Biophysiology:

Methandrostenolone does not acknowledge acerb with the androgen receptor but still exerts its furnishings through the androgen receptor in vivo.[4] These cover affecting increases in protein synthesis, glycogenolysis, and beef backbone over a abbreviate amplitude of time. In top doses (30 mg or added per day), ancillary furnishings such as gynecomastia, top claret pressure, abscess and macho arrangement alopecia may activate to occur. The biologic causes astringent masculinising furnishings in women even at low doses. In addition, it is metabolized into methylestradiol by aromatase. This agency that after the administering of aromatase inhibitors such as anastrozole or aminoglutethimide, estrogenic furnishings will arise over time in men. Abounding users will action the estrogenic ancillary furnishings with Arimidex, Nolvadex or Clomid. In addition, as with added 17α-alkylated steroids, the use of methandrostenolone over continued periods of time can aftereffect in alarmist accident after adapted care.

The 17α-methylation of the steroid does acquiesce it to canyon through the alarmist with alone a baby allocation of it torn down (hence causing the above accident to the liver) acceptance it to be able if taken orally. It aswell has the aftereffect of abbreviating the steroid's affection for sex hormone bounden globulin, a protein that de-activates steroid molecules and prevents them from added reactions with the body. As a result, methandrostenolone is decidedly added alive than an agnate abundance of testosterone, consistent in accelerated advance of beef tissue. However, the accessory acclivity in estrogen levels - a aftereffect of the aromatization of methandrostenolone - after-effects in cogent baptize retention. This gives the actualization of abundant assets in accumulation and strength, which prove to be acting already the steroid is discontinued and baptize weight drops. Because of this, it is generally acclimated by bodybuilders alone at the alpha of a "steroid cycle", to facilitate accelerated backbone increases and the actualization of abundant size, while compounds such as testosterone or nandrolone with continued acting esters physique up in the physique to an apparent bulk able of acknowledging anabolic action on their own.


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Tuesday, July 30, 2013

What is Stanozolol?




Stanozolol is White or about white apparent powder, odorless. About baffling in water, acrid in alcohol, chloroform, hardly acrid in acetone. Confined stored. This artefact anabolic action of the macho role of able and anemic adverse basis of about 120. For the analysis of a array of accompanying vascular diseases, such as Behcet's affection (Behcet syn-drome) in the vascular phenomena, ancestral angioneurotic edema, Raynaud's syndrome, apparent thrombophlebitis, venous ulcers . Can be acclimated for abiding crumbling disease, osteoporosis, and analysis with advance hormone Turner affection accepted (Turn-erssyndrome). Adverse reactions with Nandrolone.

Clinical application:
Female patients advised with androgens or anabolic hormones, can could could cause adult phenomenon, such as hirsutism, a continued beard, complete thicker and low tone, acne, usually in abandonment affection may gradually subside. Macho patients with abiding use of this chic of hormones, drugs may be adapted to estrogen in the body, and may arrest gonadotropin beard acquired testicular decline and inhibition of spermatogenesis; due to abolishment of autogenous testosterone production, can advance to impotence; Children's abiding appliance androgens, can actively affect advance and development, such as dispatch acting on epiphyseal cease can still abide for several months afterwards stopping; appliance anabolic hormones, can advance to obesity. 17 There are α-methyl androgen furnishings on the alarmist accident is added austere arrest with intrahepatic acerbity capillary above excretory function, so that the axial lobular capillary cholestasis in acerbity duct, causing cholestatic alarmist corpuscle damage, analytic manifestations of acerbity cholestatic hepatitis. Abiding use of androgen, may be alarmist cancer, prostate blight and renal corpuscle carcinoma. In addition, because there is sodium assimilation effect, can could could cause edema. Acclimated with attention in patients with branch ache and affection failure, abundant women were banned for prostate cancer

Adverse reactions:
1. Women: Abiding use may accept acne, hirsutism, clitoral hypertrophy, amenorrhea, or menstrual disorders embolism.

2. Male: Abiding use may accept acne, decreased sperm, berry reduced.

3. Liver: GOP, GTP increased, jaundice.

4. Digestive system: nausea, vomiting, dyspepsia, diarrhea.

5. Electrolytes: sodium assimilation and edema. 6. Skin: rash, facial flushing.


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