IM-54 role

A cell-permeable mono-indolylmaleimide admixture that selectively blocks oxidative stress-induced baleful corpuscle afterlife (~3 µM IM-54 prevented ~50% corpuscle afterlife in HL60 beef apparent to 100 µM H2O2). Does not action aegis adjoin Etoposide- (Cat. No. 341205) induced apoptosis or affectation antioxidant properties. Does not affect the kinase activities of S6K1 and PKC isozymes even at concentrations as top as 50 µM.
CAS No.:861891-50-1
Yellow orange solid. Packaged beneath apathetic gas.
Storage Conditions:Shipped at Ambient Temperature. Store at +2 - 8°C.
Properties:
Solubility: DMSO (100 mg/ml) or Methanol (10 mg/ml).PubChem ID:26759222
Empirical Formula:C19H23N3O2
Alternate Names:2-(1H-Indol-3-yl)-3-pentylamino-maleimide
Oxidative stress-induced afterlife plays an important role in ischemia-reperfusion injury, such as achievement and affection attack. Here, we call the development of careful inhibitors of necrosis, MS-1 and IM-54, as abeyant cardioprotective agents and biological accoutrement for investigating the atomic mechanisms of corpuscle death. By agency of actinic modifications of kinase inhibitor BM I, its affection for assorted kinases was auspiciously removed and a almighty and careful inhibitor of necrosis, IM-54, was obtained. IM-54 inhibits afterlife induced by oxidative stress, but not apoptosis induced by anticancer drugs.


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