Calcitonin is the regulation of calcium metabolism, parathyroid hormone inhibition of one, it can significantly reduce the high turnover bone disease of bone loss, such as osteoporosis, deformed bone disease (Paget's disease), pain nerve dystrophy (Sudeck's disease) and malignant osteolysis syndrome, its postmenopausal osteoporosis bone torso more significant effects than limbs and high turnover bone disease than the low turnover bone disease more pronounced. Can inhibit osteoclast activity, and stimulation of osteoblast formation. Calcitonin also inhibits osteolysis, so pathologically elevated blood calcium concentration is reduced, and by reducing the increase tubular reabsorption calcium, phosphorus and sodium excretion, serum calcium but does not fall below the normal range . Calcitonin inhibition of gastric and pancreatic secretory activity, but does not affect the stomach and intestines. Clinical trials prove that the product of some painful bone disease in patients with analgesic effect. All calcitonin structurally similar, with a single chain of 32 amino acids arranged differently. Sequence of amino acids depending on the species. Salmon calcitonin its receptor with high affinity binding site (receptor binding site of its central nervous system has been shown in certain regions), with a very good clinical results and ratio combining mammals (including humans) calcitonin, effect lasted longer.
Salcitonin Acetate indications:
1, disabled, or can not use conventional estrogen combination therapy with calcium preparations early and late postmenopausal osteoporosis and senile osteoporosis.
2, secondary to breast, lung or kidney cancer, myeloma and other malignant hypercalcemia caused by bone metastases.
3, Paget's disease.
4, hyperparathyroidism, lack of activity or vitamin D intoxication (including acute or chronic toxicity).
5, painful nerve dystrophy or Sudeck's disease.
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