N6-Methyladenosine (m6A ) is an abounding modification in mRNA and is begin aural some viruses, and a lot of eukaryotes including mammals, insects, plants and yeast. It is aswell begin in tRNA, rRNA, and baby nuclear RNA (snRNA) as able-bodied as several continued non-coding RNA, such as Xist.
Adenosine methylation is directed by a ample m6A methyltransferase circuitous absolute METTL3 as the SAM-binding sub-unit. In vitro, this methyltransferase circuitous preferentially methylates RNA oligonucleotides absolute GGACU and a agnate alternative was articular in vivo in mapped m6A sites in Rous bump virus genomic RNA and in bovine prolactin mRNA.
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From:Chemical Reagent
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