A (3R) _1_ [(IR, 2R)-2_ [2_ (3,4 _ dimethoxyphenyl) ethoxy] cyclohexyl] -3 - ol pyrazole slightly burned, characterized in that , said method comprising the steps of: (1) (3R) - pyrrolidin-hydroxy protecting agent and a silane under the action of a base protected silylated to give (R)-N-protected-3-silane - hydroxy-pyrrolidine; ( 2) in step (a) the resulting (R)-N-protected-3 - hydroxy-pyrrolidine under the action of a base and benzyl chloride or benzyl bromide reacted (R)-N-protected-3-silane - group section pyrrole burning; (3) in the step (2) the resultant (R)-N-protected-3-silane - benzyloxy-pyrrolidine-stripped under the action of an acid protecting group may silane (3R) - benzyloxy-pyrrolidine; (4) the step (3) Income (3R) - After benzyloxy pyrrolidine and cis-1 ,2 Epoxycyclohexane by ring-opening reaction, and then split too (IR, 2R) - [(3R) -3 - benzyloxy-1 - pyrrolidinyl] cyclohexanol; (5) in step (4) obtained (IR, 2R) - [(3R) _3_ section-l - pyrazol slightly alkyl] cyclic hexanol and 4 - (2 - haloethyl) _1 2 - dimethoxyphenyl reacted (3R)-l-[(IR, 2R) ~ 2 ~ [2 ~ (3, 4 - dimethyl methoxyphenyl) ethoxy] cyclohexyl] oxy pyrrole _3_ burning section; (6) of step (5) the resulting (3R) -1 - [(IR, 2R) ~ 2 ~ [2 ~ (3, 4 - dimethoxyphenyl) ethoxy] cyclohexyl] oxy pyrazole section slightly burned _3_ debenzylated to give (3R) _1_ [(IR, 2R) _2-[2_ (3,4 _ dimethoxyphenyl yl) ethoxy] cyclohexyl] -3 - pyrrolidinol.
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(R)-3-Benzyloxy Pyrrolidine Hcl prices
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Acridine Raw Material
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