Tuesday, July 30, 2013
What is Stanozolol?
Stanozolol is White or about white apparent powder, odorless. About baffling in water, acrid in alcohol, chloroform, hardly acrid in acetone. Confined stored. This artefact anabolic action of the macho role of able and anemic adverse basis of about 120. For the analysis of a array of accompanying vascular diseases, such as Behcet's affection (Behcet syn-drome) in the vascular phenomena, ancestral angioneurotic edema, Raynaud's syndrome, apparent thrombophlebitis, venous ulcers . Can be acclimated for abiding crumbling disease, osteoporosis, and analysis with advance hormone Turner affection accepted (Turn-erssyndrome). Adverse reactions with Nandrolone.
Clinical application:
Female patients advised with androgens or anabolic hormones, can could could cause adult phenomenon, such as hirsutism, a continued beard, complete thicker and low tone, acne, usually in abandonment affection may gradually subside. Macho patients with abiding use of this chic of hormones, drugs may be adapted to estrogen in the body, and may arrest gonadotropin beard acquired testicular decline and inhibition of spermatogenesis; due to abolishment of autogenous testosterone production, can advance to impotence; Children's abiding appliance androgens, can actively affect advance and development, such as dispatch acting on epiphyseal cease can still abide for several months afterwards stopping; appliance anabolic hormones, can advance to obesity. 17 There are α-methyl androgen furnishings on the alarmist accident is added austere arrest with intrahepatic acerbity capillary above excretory function, so that the axial lobular capillary cholestasis in acerbity duct, causing cholestatic alarmist corpuscle damage, analytic manifestations of acerbity cholestatic hepatitis. Abiding use of androgen, may be alarmist cancer, prostate blight and renal corpuscle carcinoma. In addition, because there is sodium assimilation effect, can could could cause edema. Acclimated with attention in patients with branch ache and affection failure, abundant women were banned for prostate cancer
Adverse reactions:
1. Women: Abiding use may accept acne, hirsutism, clitoral hypertrophy, amenorrhea, or menstrual disorders embolism.
2. Male: Abiding use may accept acne, decreased sperm, berry reduced.
3. Liver: GOP, GTP increased, jaundice.
4. Digestive system: nausea, vomiting, dyspepsia, diarrhea.
5. Electrolytes: sodium assimilation and edema. 6. Skin: rash, facial flushing.
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From:Hormones product
Sunday, July 28, 2013
16a, 17a-Epoxyprogesterone Information Introduction
CAS No.: 1097-51-4
English name: 16a, 17a-Epoxyprogesterone
English Synonyms: W-oxide; ZK-5197; EPOXY PROGESTERONE; 16a, 17a-Epoxyprogest; 16,17-EPOXYPROGESTERONE; 16,17 a-Epoxyprogesterone; 16-17A-Epoxyprogesterone; 16A, 17A-EPOXY PROGESTERONE; 16,17-ALPHA -EPOXYPROGESTERONE; 16 alpha ,17-epoxyprogesterone
Chinese name: 16,17 - Epoxyprogesterone
Chinese Synonyms: Epoxy progesterone; epoxyprogesterone; Wolfowitz oxide; fertile type oxides; Albright oxide; 16,17 - Epoxyprogesterone; 16,17 α-epoxy progesterone; 16α, 17α-epoxyprogesterone; 16,17 ALPHA epoxyprogesterone; 16α, 17α-epoxy progesterone -4 - ene-3 ,20 - dione
CBNumber: CB8156077
MF: C21H28O3
Molecular Weight: 328.45
MOL File: 1097-51-4.mol
16,17 - Epoxyprogesterone chemical properties
Melting point: 200C
Refractive index: 168 ° (C = 1, CHCl3)
Storage conditions: -20 ° C
CAS DataBase Reference: 1097-51-4 (CAS DataBase Reference)
Safety Information:
WGK Germany: 3
RTECS Number: TU5022000
16,17 - Epoxyprogesterone Properties, Usage, Production
Chemical Properties: white crystalline powder, odorless, slightly soluble in the alcohol, methanol, toluene. M.p. 201 ℃.
Purpose: cortisone acetate, hydrocortisone, megestrol acetate, progesterone caproate other drug intermediates, intermediates for the pharmaceutical progesterone caproate
Production methods: available diosgenin by ring opening, acetylation, oxidation, hydrolysis, elimination, epoxidation, oxidation step reaction of the goods.
More about:16a,17a-Epoxyprogesterone Prices
From:Hormones product
Friday, July 26, 2013
Some uses of Dehydroepiandrosterone
Dehydroepiandrosterone is white or yellow crystals. Intermediates for the manufacture of steroid hormones, with assimilation of anti-aging and protein. Main features: 1 aging, to maintain the vitality of youth; 2 to enhance physical fitness, improve mood and sleep,improve memory; 3 improve sexual function, enhance sexual desire; 4 regulate the immune system function, improve the body immunity, 5 weight loss; 6 in treatment of disease
The body's hormonal, each with their own unique features, and with the age increase and decrease, as we get older, melatonin and DHEA will gradually reduce. Generally speaking, the most important function of melatonin on the normal human is controlling the biological clock, to maintain the body's natural balance, and the average person in 17 ~ 20 years old, began to secrete DHEA,melatonin secretion decreased year by year. The curves of DHEAand melatonin secretion is slightly different, in general, has a close interaction between the two of them. DHEA is in the role of people awake, help us to control emotion, memory and learning in the psychological state, and in the physical state, DHEA can let usstrengthen the muscle strength, good proportion of maintaining muscle and fat, the body tightly lean, and help us to syntheticmetabolism role, stimulate the secretion of growth hormone, andthe regulation of immune system function. But in the evening, the secretion of DHEA slowed down gradually, so the pineal glandbegins to melatonin secretion, subtle and formed between the two.So we will be at night because of the relationship betweenmelatonin and feel sleepy, needs to rest, so DHEA has a neutralcan produce pure hormones, emotions and energy to our stableduring the day. The relationship between the two: DHEA forcortisol increases along with the age growth, while the other one is sharply decreased adrenal technology DHEA. Convenient saliva test can provide balance approach and method of these twoimportant hormones for us. Nevertheless, DHEA can beempirically for the relief of cortisol or hyperadaptosisoverproduction symptoms. DHEA can improve the glucosetolerance, the excess body fat into muscle, relieve depression,increase body energy, reduce chronic fatigue and fibromyalgiapatients physical pain, relieve joint pain and inflammation andautoimmune disease resulting fatigue, improve the mental status and provide the overall immune function of the body. Althoughnutrition is an important factor of the reasonable excess cortisol,but only one factor. The best method for reducing excess cortisol value complete need not only includes nutritional supplements,also need to take into account the movement decompression anddecompression of thinking. A study by Illinois university professor Edward Mcauley and kinematics of the Biology Department of Zhejiang University Dr. Kong Dehua common findings, aerobic exercise compared with sedentary habits can significantly improve the symptoms of anxiety. A study published in the "Journal of sport and exercise psychology" discovery ", devoted all his life to the regularity of meditation exercises can relieve pressure and reduce the side effect on cortisol value Benson MD author of" therelaxation response. The researchers another in this field havethe outstanding contribution is Massachusett University JonKabat-Zinn, Ph.D. he is "disaster survival" the author of one book,this book provides us how to complete the survival plan and optimal health through meditation. When it comes to the pressure,I always know it is a do not like things, but, in the end, it seems to us pressure is a very easy to solve the problem. DHEA metabolites: metabolites androstene diol (androstenediol-AED)and (androstenetriol, AET) has more viral and bacterial infectionability, decrease the incidence and mortality of cortisolmetabolites: four hydrogen cortisol is the main product ofmetabolism of cortisol, urinary cortisol metabolite excretion in 45%~ 50%. Four hydrogen cortisol can also be further in C20 ketoneradical generation skin five alcohol hydroxyl, urine dischargeaccounted for about 20% of the volume of.
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From:Hormones product
Thursday, July 25, 2013
The role and use Premarin
Function and use: Premarin is a natural substance extracted from estrogen mixtures, which can effectively control the organizational changes associated with menopause caused by vaginal and urinary disorders genital areas. Clinically applicable due to menopause caused by fever, sweating, hot flashes, as well as atrophic vaginitis (vaginal dryness, itching, burning sensation) reduce its symptoms. But also the prevention of osteoporosis, and the treatment of certain cancers.
Dosage: ① treatment of atrophic vaginitis; orally every piece 300μg, 625μg 900μg-1.25mg, periodic administration. ② low levels of estrogen, the female hypogonadism: day 2.5-7.5mg. ③ ovariectomy or primary ovarian insufficiency: the 1st 1.25mg. ④ osteoporosis, 1, 625μg, periodic administration. ⑤ certain breast cancers, and certain men with metastatic disease: one day three times a 10mg, a treatment for at least three months, according to different situations and different responses after treatment, appropriate dose adjustment.
Side effects and precautions: may have nausea, vomiting, headache, dizziness, menstrual changes, edema, and changes in libido and other side effects. Large doses, can increase the risk of uterine cancer, breast cancer incidence will be higher, but also increase the risk of hemorrhagic diseases. Suffering from circulatory system diseases, serious heart abnormalities of coagulation phenomena were banned.
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From:Hormones product
Monday, July 22, 2013
What is Trenbolone?
Trenbolone is similar to the popular steroid nandrolone, they are at 19 or steroids, which means testosterone molecule has been in the first 19 to give us a new compound changed. Different nandrolone however trenbolone is an excellent mass and hardening drug muscle fibers are most of the gains minimal water retention, it has an unbelievable anabolic (muscle building) 500 points. When you compare that to testosterone, which itself is a powerful mass builder, and assimilation of 100 points you can start comprehend the muscle building potential of trenbolone. What makes trenbolone and other assimilated? Many factors are at play. Trenbolone greatly increases the extremely anabolic hormone levels within the muscle tissue IGF - 1
. Moreover, it is worth noting that it is only a 2-fold increase in muscle, which causes muscle satellite cells (cells that repair damaged muscle) can be more sensitive to IGF - 1 and other growth factors IGF-1 levels. Each muscle cell DNA content can be significantly improved. Trenbolone also has a pair of androgen receptor (AR strong affinity), with more intense than testosterone. This is important because a strong androgen steroid receptor binding better muscle growth in the active steroid Airport Railway dependent mechanism. There is also evidence that strong support is very tightly coupled compounds in androgen receptors in fat loss aid also. Feel like a lock and key androgen receptor, some keys (androgens) opening (binding) the locks (receptors) are better than others. This is not to say that machine iron binding, the effect of steroids is the last word. Anadrol does not have any binding AR and measurable, we all know how potent Anadrol large-scale construction yes.
Trenbolone increases nitrogen retention of muscle tissue. This is because nitrogen retention is an anabolic substance is a strong indicator of how the description. However, trenbolone incredible impact of large-scale construction is not over yet. Trenbolone binding and anti-anabolic (muscle receptors destructive capacity) glucocorticoids. This may also inhibit catabolism (muscle damage effects) hormone cortisol.
However, it must be noted that other trenbolone amazing feature is its ability to improve feed efficiency and mineral absorption of the drug administered to an animal. To help you understand what this means you, feed efficiency is a measure of how an animal into a meat diet, and more food needs in order to produce this meat, low efficiency. In contrast, the production of meat required less food, higher efficiency and your idea is very good. Animals, regardless of trenbolone obtain high-quality diet adjustment weight, thus improving feed conversion efficiency. Looking for new compounds can improve feed conversion efficiency is 10 billion dollar industry, and spawned in the past (conjugated linoleic acid, whey protein decades, many in the world bodybuilding nutrition progress, and HMB compounds have remembered the first was first introduced livestock industry). What is converted to the hard training athlete? The food you eat will make better use of building lean muscle, vitamins and minerals, but also may allow you to better absorb health in the loop.
Trenbolone is a highly male hormone testosterone, it has the ratio of a 100-androgens; trenbolone androgen ratio is staggering 500. Androgenic steroids are appreciated for their influence and change the estrogen / androgen ratio, thus reducing water and under the skin. As if the report on trenbolone was not good enough, it gets better; Trenbolone is very good as a fat loss agent. This is a partition of its powerful role in promoting the nutritional causes. It is a little known fact is that androgen receptors are present in the fat cells and muscle cells, androgens act directly on fat cells in the iron and affect fat burning. AR androgen binding strength, higher lipolysis (fat burning) effect on adipose tissue (fat). Since some steroids even increase the AR and the amount of fat in the muscle, fat loss of this kind will work with other compounds, such as testosterone, while use of amplification.
Trenbolone promote red blood cell production and increases glycogen replenishment rates, significantly improving recovery. Like almost all steroids, trenbolones impact on the human body has a higher dose intensity maximum of the composition and dose-dependent effect. Psychological changes are a notorious side effect of trenbolone use, androgens in the brain, promote positive behavior, can be used for those who want to improve the speed and power athletes beneficial increase chemicals.
Trenbolones chemical structure makes it aromatase (conversion to estrogen), thus no trenbolone converted to estrogen ratio. Trenbolone government will not promote estrogenic side effects, such as male breast tissue growth (breast, bitch tits) accelerated fat gain, trenbolone reduces lipolysis and water retention. Trenbolone is also resistant to 5 - α-reductase enzyme, the enzyme can be reduced more androgenic steroid in the form of a number of cases, but this is not important in trenbolones, trenbolone has 1500 androgen ratio, it is very likely to cause adverse androgenic side effects in any steroid.com member who is hair loss, prostate enlargement, oily skin and acne easy case report. Unfortunately, the potential negative side effects trenbolones more than that. Trenbolone is also a famous luteinizing hormone: it combines the female hormone progesterone receptor with approximately 60% of the strength of the progesterone (). Steroid.com in the sensitive member, which may lead to breast swelling and growth Worse, trenbolones active metabolite17beta - trenbolone affinity of progesterone receptor (PGR) so that actually more than progesterone itself. Although there is no need to panic, anti-estrogen letrzole or fulvestrant can lower progesterone levels, and combat any progestenic sides. A 19-nor compound like trenbolone also increases prolactin and use. Bromocriptine or cabergoline are often recommended to reduce prolatin level. Testicular atrophy (shrinking balls) may also occur; throughout the life cycle can prevent this intermittent chorionic gonadotropin. Is also wise to closely monitor their tren users cholesterol levels, as well as kidney function and liver enzymes, as Tren may adversely affect all the features. Trenbolone, as a powerful progestin, will also shut down the production of natural testosterone even a relatively small dose of testosterone levels, and maintain a longer period of repression, which can reduce libido and cause erectile dysfunction (fina guy). It is essential that you always stack testosterone trenbolone.
More about:Trenbolone Sales
From:Chem pharma
Wednesday, July 17, 2013
About the Drostanolone Propionate
Drostanolone Propionate is a almighty constructed androgenic anabolic steroid agnate to testosterone. Drostanolone Propionate is adumbrated in postmenopausal women with alternate breast cancer, in a accumulated hormone therapy.
Pharmacology:
Drostanolone Propionate is a constructed androgen, or macho hormone, agnate to testosterone. Drostanolone Propionate works by adhering itself to androgen receptors; this causes it to collaborate with the locations of the corpuscle complex in the authoritative of proteins. It may could could cause an access in the amalgam of some proteins or a abatement in the amalgam of others. These proteins accept a array of effects, including blocking the advance of some types of breast blight cells, aesthetic beef that could could cause macho animal characteristics, and aesthetic the assembly of red claret cells.
Warnings:
Patients should be instructed to address any of the following: nausea, vomiting, changes in derma color, and abate swelling.
Males should be instructed to address too common or assiduous erections of the penis and females any hoarseness, acne, changes in menstrual periods or access in facial hair.
Interactions:
Androgens may access acuteness to articulate anticoagulahts. Dosage of the anticoagulant may crave abridgement in adjustment to advance satisfactory ameliorative hypoprothrombinemia.
Concurrent administering of oxyphenbutazone and androgens may aftereffect in animated serum levels of oxyphenbutazone.
In diabetic patients, the metabolic furnishings of androgens may abatement claret glucose and therefore, insulin requirements.
Contraindications :
Known hypersensitivity to the drug
Males with blight of the breast
Males with accepted or doubtable blight of the prostate gland
Women accepted or doubtable to be pregnant
Patients with austere cardiac, hepatic or renal disease
Mechanism Of Action:
Drostanolone Propionate is a constructed androgenic anabolic steroid and is about 5 times as almighty as accustomed methyltestosterone. Like testosterone and added androgenic hormones, dromostanolone binds to the androgen receptor. It produces assimilation of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acerbic catabolism. The antitumour action of drostanolone appears accompanying to abridgement or aggressive inhibition of prolactin receptors or estrogen receptors or production.
This artefact was added to our catalog
on Thursday 08 September, 2011.
More about:Drostanolone Propionate Sales
From:Hormones product
Monday, July 1, 2013
Valacyclovir hydrochloride pharmacokinetics
Valacyclovir hydrochloride is the forerunner of acyclovir into
acyclovir anatomize in vivo to arrest the virus. Adjoin HSV Ⅰ (HSV-Ⅰ)
and canker canker virus Ⅱ (HSV-Ⅱ) able inhibition of varicella zoster
virus, EB virus and cytomegalovirus anemic inhibition. The apparatus is
to absolute the viral DNA amalgam and arrest its replication.
Valacyclovir hydrochloride rapidly captivated afterwards articulate
administering and adapted to acyclovir, acyclovir affectionate claret
aiguille time of 0.88-1.75hr. Articulate bioavailability was 67 ± 13%,
is 3-5 times acyclovir. Valacyclovir hydrochloride articulate
assimilation broadly distributed, can be broadcast to all the 14 kinds
of tissues, including the stomach, baby intestine, kidney, liver, lymph
nodes and derma tissue in the accomplished concentration, the everyman
assimilation of academician tissue. Valacyclovir hydrochloride in vivo
afterwards articulate administering is rapidly captivated absolutely
into acyclovir, metabolites mainly alone in urine, which accounted for
46% -59% acyclovir 8 - hydroxy-9 - guanine accounted for 25 % -30%, 9 -
hydroxy-methoxy-methyl guanine accounted for 11% -12%. Affectionate
acyclovir afterwards articulate administering of single-phase
abolishment half-life of 2 advantageous volunteers demography the
artefact 250 ~ 2000mg, into the claret aggregate and aiguille claret
assimilation (Cmax) and dose-linear. The assimilation of ACV, articulate
200 ~ 400mg, the beeline relationship,> 600mg saturated curve,
oral> 800mg, captivated into the bloodstream best dosing increases.
Added articulate dosage (600mg) of VACV and ACV, aiguille time (Tmax)
were 2.10 and 3.27h; aiguille concentrations were 5.03 and 1.53mg / L.
ACV VACV in the physique into locations by the liver, its above
metabolite in the urine, which accounted for 46% of ACV to 59%, 8 -
hydroxy Acyclovir accounted for 25% to 30%, 9 - hydroxy-methoxy-A
guanine abject accounted for 11% to 12%. Claret protein bounden bulk is
actual low, calmly through the biofilm. ACV afterwards articulate
abolishment half-life of affectionate 3h.
Valacyclovir hydrochloride into the animal physique rapidly addle into L-valine and acyclovir. The above is complex in accustomed physiological and biochemical metabolism of the body, the closing is the canker virus-infected cells, viral thymidine kinase phosphorylation to become a individual phosphate compound, again the beef become diphosphate kinase phosphorylation and triphosphate compounds. Triphosphate compounds are anti-viral substances, can arrest the viral DNA polymerase, abortion of DNA synthesis, appearance antiviral efficacy. Since the amino acerbic ester of ACV artefact is no chargeless hydroxyl accumulation to phosphorylation, which is not adapted to ACV before, no antiviral activity, which it is not like the added forerunner drugs such as valaciclovir (desciclovir), etc. an added baneful to cells. Someone in Vero beef in vitro antiviral archetypal observed, including VACV, including amino acerbic esters of acyclovir adjoin canker canker virus blazon Ⅰ (HSV-1) accept a assertive effect, IC50 bulk of 0.84 ~ 10.5μmol / L, which , VACV0.84μmol / L, ACV0.1μmol / L [4]. HSV-1 was able application mice or dissection archetypal of HSV-2 infection, the use of VACV treatment, while ACV as a control. VACV accepted above ability of ACV, and the HSV-1 and HSV-2 agnate sensitivity, and added appropriate treatment, the beneath bulk of virus infection, the better. Has been begin that acyclovir triphosphate inhibits HBV, woodchuck hepatitis and avoid hepatitis B DNA polymerase, thereby interfering with viral DNA replication, and in vitro abstracts ACV does not arrest the virus. Clinically, this artefact is now acclimated for the blockage and analysis of patients with assorted allowed deficiencies canker virus infections. Late H Ⅳ and accompanied by abbreviation the amount of CD4 lymphocytes in patients decumbent to accelerating or alternate mucocutaneous canker virus infections, ACV has apparent accretion resistance, as analytic problems, use the artefact afterwards The bearings has been decidedly improved.
more about: Valacyclovir Hydrochloride
from: biomedicine
Valacyclovir hydrochloride into the animal physique rapidly addle into L-valine and acyclovir. The above is complex in accustomed physiological and biochemical metabolism of the body, the closing is the canker virus-infected cells, viral thymidine kinase phosphorylation to become a individual phosphate compound, again the beef become diphosphate kinase phosphorylation and triphosphate compounds. Triphosphate compounds are anti-viral substances, can arrest the viral DNA polymerase, abortion of DNA synthesis, appearance antiviral efficacy. Since the amino acerbic ester of ACV artefact is no chargeless hydroxyl accumulation to phosphorylation, which is not adapted to ACV before, no antiviral activity, which it is not like the added forerunner drugs such as valaciclovir (desciclovir), etc. an added baneful to cells. Someone in Vero beef in vitro antiviral archetypal observed, including VACV, including amino acerbic esters of acyclovir adjoin canker canker virus blazon Ⅰ (HSV-1) accept a assertive effect, IC50 bulk of 0.84 ~ 10.5μmol / L, which , VACV0.84μmol / L, ACV0.1μmol / L [4]. HSV-1 was able application mice or dissection archetypal of HSV-2 infection, the use of VACV treatment, while ACV as a control. VACV accepted above ability of ACV, and the HSV-1 and HSV-2 agnate sensitivity, and added appropriate treatment, the beneath bulk of virus infection, the better. Has been begin that acyclovir triphosphate inhibits HBV, woodchuck hepatitis and avoid hepatitis B DNA polymerase, thereby interfering with viral DNA replication, and in vitro abstracts ACV does not arrest the virus. Clinically, this artefact is now acclimated for the blockage and analysis of patients with assorted allowed deficiencies canker virus infections. Late H Ⅳ and accompanied by abbreviation the amount of CD4 lymphocytes in patients decumbent to accelerating or alternate mucocutaneous canker virus infections, ACV has apparent accretion resistance, as analytic problems, use the artefact afterwards The bearings has been decidedly improved.
more about: Valacyclovir Hydrochloride
from: biomedicine
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