Protein tyrosine phosphatase involved in insulin signal transduction

After 1990 Cicirelli and other first proposed PTP-1B and insulin signal transduction related to the Xenopus oocyte microinjection of PTP-1B, hindered the insulin peptide phosphorylation of S6 and delayed insulin promote oocyte maturation. This study marks a milestone reveals the PTP-1B negative regulatory role in insulin signal transduction. PTP1B specific hydrolysis of an aromatic acid, such as phosphotyrosine (pTyr) residues of the enzyme on the phosphate through a tyrosine residue or a substrate for the insulin receptor on the dephosphorylation of the insulin signal transduction guide were negative regulator, tissue cells overexpressing PTP-1B will reduce PTK activity, so that the insulin receptor can not be combined with insulin, thereby causing insulin resistance, ultimately leading to type 2 diabetes.
Elchebly such as the use of gene knockout technology, PTP-1B knockout mice were insulin resistance and sensitivity studies, a clear relationship between PTP-1B and type 2 diabetes and obesity diseases. The study found that in the PTP-1B knockout mice skeletal muscle and liver, insulin receptor autophosphorylation increased insulin sensitivity increase, and resistance to weight gain. The study defined the PTP-1B is the treatment of type 2 diabetes and obesity targets, indicating that PTP-1B inhibitors by improving insulin sensitivity, which can effectively treat type 2 diabetes and obesity.

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Olive Leaf Extract essence has protection - oxidation and repair action

1, protective antioxidant effect, keep skin cell viability
Ultraviolet light can cause the formation of free radicals, which damage the skin cells, and even cell death in the morning. Suppose to exposed skin cells Yu Guangzhao, look at the cutin cell with the change of fiber cells, some with pure Olive Leaf Extract essence, others do not, 24 hours after their conditions of cells, and found that: with pure Olive Leaf Extract essence cells almost preserved intact.
2, protection - oxidation reaction
Ultraviolet ray also can cause cell membrane lipid decomposition, this kind of imagination is peroxidation. The skin fiber cells culture, some with pure Olive Leaf Extract essence, others not. After heritage fluorescence analysis measurement in the process of decomposition secrete a kind of special material to measure the degree of peroxidation. Experimental results show: pure Olive Leaf Extract essence can effectively organize peroxidation, thus highly protected fiber cells.

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The role of the understanding of Pumpkin Seed Extract

1, detoxification:
Contains vitamins and pectin, pectin has good adsorption, can be bonded and eliminate bacteria in the body toxins and other harmful substances, heavy metals such as lead, mercury and radioactive elements, can play the detoxification;
2, protect the gastric mucosa, help digestion,
Pumpkin contains pectin also can protect the gastric mucous membrane of groove, from coarse food stimulation, promote ulcer healing, suitable for the patients with stomach problems. Pumpkin contains ingredients can promote bile secretion, enhance the gastrointestinal peristalsis, help digestion of food.
3, the prevention and treatment of diabetes, and lowering blood sugar:
Pumpkin is rich in cobalt, cobalt can active the metabolism of human body, promote hemopoietic function, and participants, the synthesis of vitamin B12 is essential for human islet cells of trace elements, for the prevention and treatment of diabetes, lower blood sugar have special curative effect;
4, eliminate carcinogenic substances:
Pumpkin can eliminate mutation of carcinogenic nitrosamines, have anti-cancer effect, and can help the recovery of liver, kidney, enhance the regeneration of liver and kidney cells;
Five, promote the growth and development:
Pumpkin is rich in zinc, participants in the body of nucleic acid, protein synthesis, is the intrinsic element of the adrenal cortical hormone, growth and development of important material to the human body.

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Avena sativa - nutritional value

According to comprehensive analysis of the health of the Chinese academy of medical sciences institute, China naked Avena sativa coarse protein content reaches 15.6%, fat 8.5%, starch and release heat and phosphorus, iron, calcium and other elements, compared with the other eight food, are leading the way. Avena sativa in water-soluble dietary fiber are respectively 4.7 times and 7.7 times of wheat and corn. Avena sativa in the B vitamins folic acid, niacin, is rich, pantothenic acid, vitamin E, in particular, every 100 grams of Avena sativa is as high as 15 mg powder. In addition Avena sativa powder also contains all of cereal food, lack of saponins (the main composition of ginseng). Protein amino acid composition of comprehensive, 8 kinds of essential amino acid content in the first place, especially lysine is as high as 0.68 g.
Avena sativa rice cooked porridge is rich in magnesium and vitamin B1, also contains phosphorus, potassium, iron, pantothenic acid, copper and fiber, can lower cholesterol and the fatty liver disease, diabetes, constipation, etc. Also have assisted effect. Without cooking, Avena sativa bran is rich in magnesium, vitamin B1, phosphorus, potassium, also contain iron, zinc, folic acid, pantothenic acid and copper. Avena sativa tablet can improve the blood circulation and promote wound healing.
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Devils Claw Extract - function

Devils Claw Extract has an effect on the heart, low doses can slightly slow heart rate, increase the contractile force. High doses significantly diminished cardiac contractile force and coronary blood flow. Devils Claw also showed a weak antifungal activity. Civilian oral Devils Claw root for atherosclerosis, arthritis, gout, myalgia, fiber woven inflammation, rheumatic pain, waist pleurisy pain, rheumatism, gastrointestinal discomfort, anorexia, and movement system degenerative disease. Oral Devils Claw is traditionally used for kidney and bladder disease and menoxenia. Used as a ointment, outside for damage, etc. The curative effect of oral Devils Claw for anorexia or indigestion may be effective. Support for degenerative joint disease treatment may be effective. Other therapeutic effect without enough, make sure the information. Safety of oral and moderate with Devils Claw tuber preparations may be safe. Without enough information, make sure the safety of outside.
Devils Claw oil massage is thought to be safe, if take orally, had better follow the doctor's guidance, gastric or duodenal ulcer patients the clothing, women clothing.
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Desmodium styracifolium Extract - pharmacological effects

Anti-inflammatory effects:
Desmodium styracifolium 50 g/kg and total flavonoids and phenolic acids content by intraperitoneal injection of 3.75 g/kg, vascular permeability increase in mice caused by histamine has significant inhibitory effect, the mouse ear inflammation caused by croton oil have a very significant inhibitory effect, caused by injection of egg white in rats ankle swelling and cotton ball granuloma of rats had significant inhibitory effect.
The role of vascular smooth muscle:
Desmodium styracifolium for vascular smooth muscle relaxation effect, ADP and arachidonic acid induced in vitro platelet aggregation and has certain inhibitory effect.

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Zostera Marina (Seaweed) extract- nutrients

1. The protein:
Seaweed is a kind of special protein called glycoprotein, it to certain sugars have affinities and non covalent bonding with them. Pro glycoprotein and cell membrane after sugar molecules can cause cell sedimentation phenomenon, therefore is a kind of lectin. Pro glycoproteins are widespread in the land of plants, animals, and microorganisms, especially in the leguminous plant seeds in the rich. Characteristics of glycoprotein affinity through the identification of sugar and the biological defense, growth, reproduction, and nutrition play an important role on storage and biological symbiosis. Glycoprotein affinity can also be applied to the blood cell separation detection, drug carrier, immune antibody production, and the medicinal USES of anti-cancer drugs.
2. The polysaccharide:
In algae have immunity and antitumor activity of material, is a special polysaccharide, protein, lipid, pigment and low molecular substances. In traditional Chinese medicine, several kinds of brown algae after cooking can be used to prevent and treat cancer, the hot water extract was mostly polysaccharide.
3. Vitamin:
When some vitamin deficiency or lack of, can cause metabolic disorders and diseases. Kelp contains a variety of vitamins, main of vitamin B12, C and E, biotin and nicotinic acid. The body vitamin B12 deficiency can lead to chronic pain, anemia and fatigue, and even mental disorder; The vitamin content in the seaweed, although small, widely distributed in various kinds of algae.


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