What side effect does Pirenzepine have? Pirenzepine's indications: for gastric ulcer and duodenal ulcer, stress ulcer, acute gastric mucosal bleeding. Because the curative effect compared with H2 receptor antagonists and proton pump inhibitors, the clinical application of less. Pirenzepine; of pharmacology:Pirenzepine is the selective ML receptor antagonist, has a high affinity for ML receptors on parietal cells, smooth muscle, myocardium and salivary glands M2 receptor affinity is very low, so the amount of general treatment only can inhibit gastric acid secretion of pupil, gastrointestinal tract, heart, salivary gland is not obvious, only large doses can cause dry mouth, blurred vision, heart adverse reaction rate. Patients with duodenal ulcer were treated with oral administration of 25mg/, 3 /d, and the basal gastric acid secretion was reduced by 4 after the first 51% weeks, and the secretion of gastric acid stimulated by gastrin was reduced by about 41%, which was about five. It can inhibit the secretion of pepsin. The drug has little effect on the pH of gastric juice, mainly to reduce the secretion of gastric juice.
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