Betulinic Acid is a pentacyclic lupane-type triterpene that is broadly broadcast throughout the bulb kingdom. A array of biological activities accept been ascribed to Betulinic Acid including anti-inflammatory and in vitro antimalarial effects. However, Betulinic Acid is a lot of awful admired for its anti-HIV-1 activity and specific cytotoxicity adjoin a array of bump corpuscle lines. Absorption in developing even added almighty anti-HIV agents based on Betulinic Acid has led to the analysis of a host of awful alive derivatives announcement greater potencies and bigger ameliorative indices than some accepted analytic anti-HIV agents. While its apparatus of activity has not been absolutely determined, it has been apparent that some Betulinic Acid analogs agitate viral admixture to the corpuscle in a post-binding footfall through alternation with the viral glycoprotein gp41 admitting others agitate accumulation and alpha of the HIV-1 virus. With attention to its anticancer properties, Betulinic Acid was ahead appear to display careful cytotoxicity adjoin several melanoma-derived corpuscle lines. However, added contempo plan has approved that Betulinic Acid is cytotoxic adjoin added non-melanoma (neuroectodermal and cancerous academician tumor) animal bump varieties. Betulinic Acid appears to activity by agency of inducing apoptosis in beef irrespective of their p53 status. Because of its careful cytotoxicity adjoin bump beef and favorable ameliorative index, even at doses up to 500 mg/kg physique weight, Betulinic Acid is a actual able new chemotherapeutic abettor for the analysis of HIV infection and cancer.
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