structure Introduction of CD169

CD169, contrarily accepted as Sialoadhesin (Sn), is a blazon I transmembrane glycoprotein and prototypic affiliate of the Siglec (sialic acerbic bounden Ig-like lectin) family, appointed Siglec-1.CD169 is a macrophage-restricted alternation atom which binds to sialylated ligands on haematopoietic cells, including neutrophils, NK cells, monocytes, a subset of CD8+ T beef and B cells, through acceptance of sialic acerbic in the alpha-2,3- glycosidic linkage. CD169 is awful bidding by blooming beef and on stromal macrophages in the spleen, cartilage bottom and lymph nodes and to a bottom admeasurement in liver, lungs and gut, and studies accept apparent top announcement of CD169 on macrophages in the anarchic altitude rheumatoid arthritis and atherosclerosis. Completely inhibits corpuscle rosetting about Sn+ transductants.